Autoimmune Hemolytic Anemia
Author and Disclosure Information [Show]

Division of Hematology/Medical Oncology Oregon Health & Science University, Portland, OR

Question 1 of 5

You are called to consult on a patient with end-stage liver disease and anemia. The patient’s hematocrit is 25%. He is noted to have a direct antibody test (DAT) that is positive for IgG antibodies but negative for C3. He has a normal lactate dehydrogenase (LDH) level at 185 U/L and a normal reticulocyte count.

What is the next step in the management of this patient?

Consult surgery about splenectomy

Order measurement of ferritin level and additional laboratory tests plus review blood smear looking for other causes of anemia

Start mycophenolate 500 to 1000 mg twice daily

Start prednisone at 1 mg/kg/day

Start rituximab at 375 mg/m2 weekly × 4 weeks

This quiz is not accredited for CME.

More from Board Review Questions: Hematology/Oncology

QUIZ

Gastrointestinal Stromal Tumors
Testicular Cancer
Management of Advanced Melanoma
Castration-Resistant Prostate Cancer
Transfusion Reactions (part 2)
Transfusion Reactions (part 1)
Plasma Cell Disorders (part 3)
Plasma Cell Disorders (part 2)
Chronic Myeloid Leukemia
Aplastic Anemia
Transfusion Medicine
Small Cell Lung Cancer
Management of Metastatic Gastric Cancer
Acute Myeloid Leukemia
Urothelial Carcinoma: Muscle-Invasive and Metastatic Disease
Management of Colorectal Cancer in Older Adults
Aggressive B-Cell Non-Hodgkin Lymphoma
HER2-Positive Breast Cancer
Pancreatic Adenocarcinoma: Advanced Unresectable and Metastatic Disease
Von Willebrand Disease: Clinical Management
Von Willebrand Disease: Assessment and Diagnostic Testing
Pancreatic Adenocarcinoma: Neoadjuvant and Adjuvant Treatment
Late Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Polycythemia Vera and Essential Thrombocythemia: Current Management
Treatment of Biliary Tract Cancers
Early Pulmonary Complications After Hematopoietic Stem Cell Transplantation
Hairy Cell Leukemia
Genomic Testing in Women with Early-Stage Hormone Receptor–Positive, HER2-Negative Breast Cancer
Immune Thrombocytopenia
Cancer-Related Fatigue
Disseminated Intravascular Coagulation
Advanced Stage and Relapsed/Refractory Hodgkin Lymphoma
Adjuvant Chemotherapy for Colon Cancer
Molecular Markers and Targeted Therapies in the Management of Non-Small Cell Lung Cancer
Metastatic Cutaneous Melanoma: Targeted Therapy and Immunotherapy
Thrombosis in Pregnancy
Locally Advanced Pancreatic Cancer
Early-Stage Hodgkin Lymphoma
Neoadjuvant and Adjuvant Therapy for Gastric Cancer
Hemophilia A and B
Mantle Cell Lymphoma
Soft Tissue Sarcoma
Sickle Cell Disease
Renal Cell Carcinoma
Management of Locally Advanced Rectal Adenocarcinoma
Adjuvant Systemic Therapy for Early-Stage Breast Cancer
Chronic Myeloid Leukemia
Plasma Cell Disorders
Myelodysplastic Syndromes
Acute and Chronic Graft-versus-Host Disease