Teva Pharmaceutical Industries Ltd. has announced that the US Food and Drug Administration (FDA) has approved Ajovy (fremanezumab-vfrm) injection for the preventive treatment of migraine in adults. Teva Pharmaceuticals is headquartered in Jerusalem, Israel.

Indications: Ajovy, a humanized monoclonal antibody that binds to calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor, is the first and only anti-CGRP treatment for the prevention of migraine with quarterly (675 mg) and monthly (225 mg) dosing options.

Dose/administration: 2 subcutaneous dosing options of Ajovy are available to administer the recommended dosage:

• 225 mg monthly, or
• 675 mg every 3 months (quarterly).

The 675 mg quarterly dosage is administered as 3 consecutive injections of 225 mg each. Dose should be administered in the abdomen, thigh, or upper arm subcutaneously.

Adverse reactions: The most common adverse reactions (≥5% and greater than placebo) were injection site reactions.