Glutamate-sensitive contrast was significantly increased in the prefrontal cortex of patients with multiple sclerosis (MS) with accumulated disability, according to a recent study. In addition, glutamate-sensitive contrast in the prefrontal cortex was significantly correlated with symbol digit modality test (r_s = −0.814) and choice reaction time (r_s = 0.772) scores in patients, suggesting that glutamate-sensitive chemical exchange saturation transfer (GluCEST) MRI may have utility as a marker for gray matter (GM) pathology and cognitive impairment (CI). A total of 20 patients with relapsing-remitting MS and 20 healthy controls underwent cognitive testing, anatomical imaging, and GluCEST imaging. Glutamate-sensitive image contrast was quantified for cortical GM, compared between cohorts, and correlated with clinical measures of CI. Researchers also found that glutamate-sensitive contrast in the prefrontal cortex was significantly correlated with symbol digit modality test (r_s = −0.814) and choice reaction time (r_s = 0.772) scores in patients, suggesting that GluCEST MRI may have utility as a marker for GM pathology and CI.