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Fibromyalgia, C-Reactive Protein Link Examined

BMC Musculoskelet Disord; ePub 2017 Jul 7; Feinberg, et al

Publish date:: July 17, 2017

A recent, large, cross-sectional study indicates a significant positive cross-sectional association of fibromyalgia to serum C-reactive protein (CRP) that can be explained, in part, by body mass index (BMI) and comorbidity. Participants were 52,535 Ohio Valley residents (fibromyalgia n=1,125) who completed a comprehensive health survey section of the C8 Health Project; serum levels of CRP were obtained, as was history of fibromyalgia physician diagnosis. Researchers found:

Mean CRP was higher among participants reporting fibromyalgia than those without.
CRP level showed a strong, positive association with fibromyalgia syndrome (FMS); adjustment for demographic and lifestyle factors attenuated, but did not eliminate, this association.
Further addition of BMI and comorbidities to the model markedly weakened this relationship.
In contrast, inclusion of mood and sleep impairment only modestly reduced the adjusted risk estimate.

Citation:

Feinberg T, Sambamoorthi U, Lilly C, Innes KK. Potential mediators between fibromyalgia and C-reactive protein: Results from a large U.S. community survey. [Published online ahead of print July 7, 2017]. BMC Musculoskelet Disord. doi:10.1186/s12891-017-1641-y.

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