Clinical Review

Peanut Allergy Awareness

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• Peanuts

• Tree nuts

• Egg

• Milk

• Wheat

• Soybeans

• Fish

• Crustacean shellfish.34

Treatment for Anaphylaxis
In pediatric patients, administration of epinephrine is the definitive treatment for anaphylaxis; both the child and parents should carry an epinephrine self-injection device at all times in the event of accidental peanut ingestion. These devices are available in two strengths, based on the child’s weight, and expiration dates should be noted with care. Correct use of the epinephrine self-injection device should be reviewed at each office visit.6

Early-stage allergic reactions can be managed by oral antihistamines, such as diphenhydramine (1 mg/kg body weight up to 75 mg) and an intramuscular injection of epinephrine.1 Prompt transport to the ED should follow (see “Management of Anaphylaxis in the ED”1,9).

PREVENTION
A 2010 expert panel on diagnosis and management of food allergy sponsored by the NIAID, NIH,3 does not advise women to restrict their diet during pregnancy and lactation. Similarly, the United Kingdom’s Department of Health and the Food Standards Agency (DHFSA)36,37 does not support the belief that eating peanuts and peanut-containing foods during pregnancy correlates with a child’s potential for developing a peanut allergy.

The DHFSA does recommend breastfeeding infants for the first six months, if possible, and that mothers refrain from introducing peanut-containing foods during that time. They also recommend that foods associated with a high risk for allergy be introduced into a child’s diet one at a time, to make it easier to identify any allergenic substance.36,37

Lastly, the DHFSA advises parents with a family history of peanut allergy to introduce peanuts only after consulting with their health care provider. The same consideration is advised if a child has already been diagnosed with another allergy.34 According to the American Academy of Pediatrics,6,38 children at high risk for food allergy (eg, atopic disease in both parents or one parent and one sibling) should be breastfed or be given hypoallergenic formula until age 1 year, with no solid foods before age 6 months; peanut-containing foods should not be given before age 3 or 4 years.

CONCLUSION
Peanut allergy can present a lifelong battle for affected patients. Eating one peanut or being exposed even to minute amounts of peanut protein could mean life or death without appropriate management. Reading food labels carefully, preparing peanut-free foods, recognizing the signs and symptoms of anaphylaxis, and obtaining the necessary treatment when allergic reactions occur are essential for peanut-allergic patients and their families.

REFERENCES
1. Burks AW. Peanut allergy. Lancet. 2008;371 (9623):1538-1546.

2. Hong X, Tsai HJ, Wang X. Genetics of food allergy. Curr Opin Pediatr. 2009;21(6):770-776.

3. Boyce JA, Assa’ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 suppl):S1-S58.

4. Sicherer S, Muñoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010;125(6):1322-1326.

5. Hourihane JO, Aiken R, Briggs R, et al. The impact of government advice to pregnant mothers regarding peanut avoidance on the prevalence of peanut allergy in United Kingdom children at school entry. J Allergy Clin Immunol. 2007;312(5):1197-1202.

6. Nowak-Wegrzyn A, Sampson HA. Adverse reactions to foods. Med Clin North Am. 2006;90(1):97-127.

7. Puglisi G, Frieri M. Update on hidden food allergens and food labeling. Allergy Asthma Proc. 2007;28(6):634-639.

8. Hefle SL. Hidden food allergens. Curr Opin Allergy Clin Immunol. 2001;1(3):269-271.

9. Lee CW, Sheffer AL. Peanut allergy. Allergy Asthma Proc. 2003;24(4):259-264.

10. Boughton B. New test for peanut allergy a step forward. www.medscape.com/viewarticle/740133. Accessed November 16, 2011.

11. Asarnoj A, Movérare R, Östblom E, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010;65(9):1189-1195.

12. Codreanu F, Collignon O, Roitel O, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis. Int Arch Allergy Immunol. 2011;154(3):216-226.

13. Sicherer SH, Furlong TJ, Maes HH, et al. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000;106(1 pt 1):53-56.

14. Green TD, LaBelle VS, Steele PH, et al. Clinical characteristics of peanut-allergic children: recent changes. Pediatrics. 2007;120(6):1304-1310.

15. Al-ahmed N, Alsowaidi S, Vadas P. Peanut allergy: an overview. Allergy Asthma Clin Immunol. 2008;4(4):139-143.

16. Björkstén B. Genetic and environmental risk factors for the development of food allergy. Curr Opin Allergy Clin Immunol. 2005;5(3):249-253.

17. Lack G. Epidemiologic risks for food allergy. J Allergy Clin Immunol. 2008;121(6):1331-1336.

18. Skolnick HS, Conover-Walker MK, Koerner CB, et al. The natural history of peanut allergy. J Allergy Clin Immunol. 2001;107(2):367-374.

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