This patient handout from the Agency for Healthcare Research and Quality discusses 4 non-pharmacologic treatment options for patients who haven’t responded to 2 or more antidepressants. The handout describes the benefits and side effects of electroconvulsive therapy, vagus nerve stimulation, repetitive transcranial magnetic stimulation, and “talk” therapy. There’s also a section on things to think about when working with a physician to select the best option. http://effectivehealthcare.ahrq.gov/ehc/products/76/1011/ref_dep_cons_fin_to_post.pdf.