Clinical Inquiries
Clinical Inquiries
Does adjunctive oxytocin infusion during balloon cervical ripening improve labor induction?
EVIDENCE-BASED ANSWER: YES. Compared to the use of a transcervical balloon alone, combined cervical ripening with a balloon catheter and oxytocin...
Clinical Inquiries
Are SERMs safe and effective for the treatment of hypogonadism in men?
EVIDENCE-BASED ANSWER: YES. For both normal-weight and obese men with low testosterone levels and hypogonadal symptoms, selective estrogen...
Clinical Inquiries
Should we stop prescribing IM progesterone to women with a history of preterm labor?
EVIDENCE-BASED REVIEW: YES, we should stop the routine prescribing of IM progesterone to prevent preterm delivery. A 2003 randomized controlled...
Clinical Inquiries
Does inadequate sleep increase obesity risk in children?
EVIDENCE-BASED ANSWER: Yes, a link has been established but not a cause-effect relationship. Shorter reported sleep duration in childhood is...
Clinical Inquiries
Which injections are effective for lateral epicondylitis?
EVIDENCE-BASED ANSWER: Placebo injections actually improve lateral epicondylitis at high rates. No other injections convincingly improve it better...
Clinical Inquiries
Is exercise therapy effective treatment for low back pain?
EVIDENCE-BASED ANSWER: Yes, it is somewhat effective. Exercise therapy—including general exercise, yoga, Pilates, and motor control exercise—has...
Clinical Inquiries
Do carotid artery calcifications seen on radiographs predict stenosis in asymptomatic adults?
EVIDENCE-BASED ANSWER: Not very well. In asymptomatic patients, carotid artery calcification seen on radiograph has a positive...
Clinical Inquiries
Can family physicians accurately screen for AAA with point-of-care ultrasound?
EVIDENCE-BASED ANSWER: Likely yes. Point-of-care ultrasound (POCUS) screening for abdominal aortic aneurysm (AAA) by nonradiologist physicians is...
Clinical Inquiries
Is event-driven PrEP dosing for HIV as effective as daily dosing?
Probably, although there are no head-to-head trials comparing the 2 dosing regimens. Event-driven pre-exposure prophylaxis (PrEP) dosing...
Clinical Inquiries
Is NPH associated with fewer adverse events than analog basal insulin for adults with T2D?
EVIDENCE-BASED ANSWER: NO. Insulin glargine may lead to less patient-reported, symptomatic, and nocturnal hypoglycemia, although overall, there...
Clinical Inquiries
Is ketamine effective and safe for treatment-resistant depression?
EVIDENCE-BASED ANSWER: MAYBE, but it’s too soon to tell. There is limited evidence that ketamine by itself is effective in the very short term....