Five patients (8%) had middle ear effusions at least once, and 16 (25%) had abnormal tympanometry or audiograms, with tube placement in 8 (12%). Increases in the size of the kidneys and spleen by ultrasound occurred in the first 2–3 years of therapy, but no adverse changes of renal function were observed. There were no deaths or neoplasias, Dr. Chernausek reported.
