The American Academy of Pediatrics recommends screening all infants twice (at age 9 to 12 months, and 6 months later) along with dietary interventions to prevent iron deficiency, such as: breast-feeding or the use of iron-fortified formula, and the introduction of iron-rich foods at age 6 months.
2. Colon cancer
The task force recommends against routine use of aspirin and NSAIDs to prevent colorectal cancer in individuals at average risk for colorectal cancer.2
Colon cancer is common and a common cause of cancer mortality,3 and proven secondary preventions are available. Chemoprevention is a potential method of primary prevention; it has some benefits as well as harms. The task force concluded that the documented harms exceed the potential benefits.
- Aspirin taken at the high-dose regimen (350–700 mg/day) needed to protect from colon cancer increases the risks for gastrointestinal bleeding and hemorrhagic stroke. A lower dose of aspirin (75–350 mg/day) is used for chemoprevention in adults who are at increased risk for coronary heart disease but this does not protect against colon cancer.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of colorectal cancer, but they also increase the risks of gastrointestinal bleeding and renal injury.
- Cyclooxygenase-2 inhibitors have been linked to increases in coronary artery disease.
3. Hemochromatosis
The task force recommends against routine genetic screening for hereditary hemochromatosis in the asymptomatic general population.4
Hemochromatosis is rare, and only a small proportion of those with the high-risk genotype actually develop the disease. The effectiveness of early intervention is unproven, and the potential for harm from false positives is significant.
The D recommendation does not apply to those with signs and symptoms consistent with hemochromatosis or a strong family history of the disease. Nor does it pertain to non-genetic laboratory tests to identify iron overload (although these also lack proof that they improve outcomes in the general population).
4. Congenital hip dysplasia
The task force concludes that evidence is insufficient to recommend routine screening for developmental dysplasia of the hip in infants as a means to prevent adverse outcomes.5
Physical examination and ultrasonography have limited accuracy in finding hip dysplasia, and there is a high rate of natural resolution (60% to 90%) of hip abnormalities found with these tests. Both surgical and non-surgical treatments lack evidence of effectiveness and are associated with potential for harm from avascular necrosis, high costs, and complications from surgery and anesthesia.
This uncertainty applies only to asymptomatic infants—not to those who have obvious hip dislocations or other hip abnormalities.
5. Elevated lead levels
The task force concludes that evidence is insufficient to recommend for or against routine screening for elevated blood lead levels in asymptomatic children ages 1 to 5 who are at increased risk.6
The task force recommends against routine screening for elevated blood lead levels in:
- asymptomatic children ages 1 to 5 years who are at average risk
- asymptomatic pregnant women.6
The reduction of lead in the environment, especially the reduction of leadbased gasoline, has resulted in a decline in elevated blood lead levels in the United States. The task force’s uncertainty regarding screening at-risk children centered around a lack of evidence of the effectiveness of interventions in decreasing blood lead levels. Other organizations that continue to recommend screening in high-risk children include the CDC and the American Academy of Pediatrics. The main risk factor for elevated blood lead levels is living in housing constructed before 1950.
The recommendation against screening in pregnant women was based on the low prevalence, no evidence for effectiveness of interventions to decrease lead levels, and potential harms from screening. This recommendation agrees with those of other organizations.
Speech delay
The task force concludes that evidence is insufficient to recommend for or against routine use of brief, formal screening instruments in primary care to detect speech and language delay in children up to 5 years of age.7
While speech delay affects 5% to 8% of children under the age of 5, and interventions can result in short-term improvements, long-term benefits have not been studied. It is also unclear whether the brief screening tools used in primary care accurately identify children who will benefit from interventions, or whether the results of early intervention are better than when difficulties are first identified by parents. Overall, the task force felt that we lack sufficient evidence to evaluate overall benefits and harms of brief formal screening tools in primary care among asymptomatic children.
Correspondence
Doug Campos-Outcalt, MD, MPA, 4001 N Third Street #415, Phoenix, AZ 85012; dougco@u.arizona.edu.