Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Must Reads by Date

Must reads for theWeek ending December 6, 2015

FDA Approves Empliciti in Multiple Myeloma, Indicated as second-line, IV therapy

FDA Approves Ninlaro in Multiple Myeloma, Indicated as second-line, oral therapy

Updated Guidelines on Cutaneous T-Cell Lymphoma, Guidelines cover diagnosis, stratification, and management

Obesity in Acute Myelogenous Leukemia, Comparing survival rates in patients with APL and non-APL AML

FDA Approves Opdivo for Advanced Renal Cell Carcinoma, Second line after prior antiangiogenic therapy

More must reads

Must reads for theWeek ending November 29, 2015

FDA Approves Darzalex, Immunotherapy indicated for multiple myeloma

Impact of Estrogen on Myeloproliferative Neoplasms, Assessing its effect on essential thrombocythemia and polycythemia vera

Hydroxyurea Therapy in Sickle Cell Disease, Does it affect survival?

Familial Clustering of Multiple Myeloma, Searching for associations with discordant cancers

More must reads

Must reads for theWeek ending November 22, 2015

FDA Approves Adynovate for Hemophilia A, For on-demand treatment and twice-weekly prophylaxis

Intravenous PEG Asparaginase in Acute Lymphoblastic Leukemia, Comparing it with intramuscular E coli asparaginase

Cytogenetic Markers in Multiple Myeloma, Studying the effects of newer therapies on prognostication

FDA Approves Cotellic/Zelboraf Combination, Used in treatment of unresectable or metastatic melanoma

More must reads

Must reads for theWeek ending November 15, 2015

ASCO Revises Guidelines on Antiemetics, Committee issues evidence-based update

Conditioning Following AlloHCT, Comparing myeloablative to reduced-intensity conditioning

Age and Incidence in Chronic Myeloid Leukemia, Studying geographic differences

ASCO Revises Guidelines on Antiemetics, Committee issues evidence-based update

More must reads

Must reads for theWeek ending November 8, 2015

Variant Allele Frequency in MDS, Do gene mutations have prognostic value?

Stem-Cell Transplantation in Older Patients, Studying survival in patients aged > 60 years

Sex Differences in AML Survival, Whom does nature favor?

Resources Available to Patients With Hemophilia, Surveying patients about HTC quality and gaps

More must reads

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