Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hypertension, white matter hyperintensities, and dementia: What’s the link?

Publish date:: July 17, 2019

Key clinical point: Uncontrolled hypertension can harm cognition through vascular pathways independent of amyloid and tau.

Major finding: The effect of uncontrolled hypertension on cognition was seen mediated by white matter hyperintensities load (P = .021) and neurodegeneration (P = .024) but not by biomarkers for amyloid or tau.

Study details: Cross-sectional data from a cohort of 2,323 subjects recruited at memory centers across France from 2011 through 2014.

Disclosures: Dr. Lespinasse and Dr. Dufouil disclosed no industry relationships.

Citation:

REPORTING FROM AAIC 2019

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