Key clinical point: In the first several years after MS onset, serum NfL levels predict deep gray matter volumes at 10 years.

Major finding: The inverse association between serum NfL levels and deep gray matter volumes remained significant in a multivariate analysis.

Study details: An examination of data for patients enrolled in the Comprehensive Longitudinal Investigations in MS at Brigham and Women’s Hospital (CLIMB) study.

Disclosures: The study was supported by funds from the U.S. Department of Defense, Novartis, and the Swiss National Research Foundation. Dr. Chitnis has received personal compensation for consulting and advisory board membership from Biogen, Merck Serono, Novartis, and Sanofi.