In adults with knee pain, a High Omega-6 to High Omega-3 (n-6:n-3) polyunsaturated fatty acids (PUFAs) ratio is associated with greater clinical pain/functional limitations, experimental pain sensitivity, and psychosocial distress compared to a low ratio group, according to a recent study. A cross-sectional investigation of clinical and experimental pain and physical and psychosocial functioning was completed in 167 adults aged 45 to 85 meeting knee osteoarthritis (OA) screening criteria. Blood samples were collected and the plasma n-6:n-3 PUFA ratio determined. Quartile splits were computed and low (n=42) and high (n=41) ratio groups were compared. Researchers found that the high ratio group reported greater pain and functional limitations, mechanical temporal summation (hand and knee), and perceived stress, but not depressive symptoms.