CONCLUSION
Gluten-free diets are increasing in popularity, and many people who do not have CD claim improved health and vitality when they avoid gluten. Much is known about the incidence and pathogenesis of the gluten-associated disorders of CD and WA. Far less is known about the controversial disorder of NCGS. The symptoms and morbidities associated with NCGS have been well documented and present a curious mix of CD and IBS, yet neither condition fully accounts for the pathogenesis of NCGS. While CD is linked to more serious morbidities (including death if the disease is not readily diagnosed), NCGS and WA do produce significant manifestations and risks.
Research into NCGS remains limited and conflicting, and biomarkers for the disorder are not yet known. Unsupported or not, many patients attribute mood disorders, pain, and chronic ills to gluten intake and seek input from their health care providers. Rather than dismiss their claims, clinicians can provide pertinent instructions on a gluten-free lifestyle and healthy diet, and encourage the use of food diaries to document food-symptom associations. Gluten sensitivities are not benign and “going gluten-free” may be of great benefit for many patients with GS. That’s a fact.
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