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Executive Dysfunction’s Role in PD, Based on MoCA

Parkinsonism Relat Disord; ePub 2017 May 25; Benge, et al

In keeping with prior studies in Parkinson disease (PD), executive dysfunction seems to underpin performance of many items of the Montreal Cognitive Assessment (MoCA), a recent study found. Researchers analyzed item responses from the MoCA in 357 individuals with PD from the Parkinson's Progression Markers Initiative for frequency of errors and polychoric inter-item correlations. This correlation matrix was then analyzed with exploratory factor analysis. They found:

  • Factor analysis revealed that the MoCA is explained by 3 factors in early PD; these factors were reflective of executive dysfunction, memory, and verbal attention.
  • Scores on the MoCA and all of its subscales were significantly different between individuals with PD and no cognitive impairment and those who met criteria for mild cognitive impairment.

Citation:

Benge JF, Balsis S, Madeka T, Uhlman C, Lantrip C, Soileau MJ. Factor structure of the Montreal Cognitive Assessment items in a sample with early Parkinson's disease. [Published online ahead of print May 25, 2017]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2017.05.023.