There was no association between urine albumin levels and risk of incident clinical fracture, according to a recent study of older men, but there was a borderline significant, positive association with rate of hip bone loss. Researchers used data from Osteoporotic Fractures in Men (MrOS), a prospective cohort study of community-dwelling men aged ≥65 years, to evaluate the association of increased urine albumin with subsequent fractures and annualized rate of hip bone loss. They found:

• Of 2,982 men with calculable albumin/creatinine ratio (ACR), 9.4% had ACR ≥30 mg/g (albuminuria), and 1.0% had ACR ≥300 mg/g (macroalbuminuria).
• During a mean of 8.7 years of follow-up, 20.0% of men had an incident clinical fracture.
• In multivariate-adjusted models, neither higher ACR quintile nor albuminuria was associated with increased risk of incident clinical fracture.
• Increased urine albumin had a borderline significant, multivariate-adjusted, positive association with rate of total hip bone loss when modeled in ACR quintiles, but not when modeled as albuminuria vs no albuminuria.